GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | SSH2 | chr17:27952965-28257018:- | -0.34 | -7.67 | 9.71E-14 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | TP53I13 | chr17:27895739-27900174:+ | -0.2 | -5.29 | 1.87E-7 | Coffee consumption (cups per day) |
| THCA | cis | rs515910 | 1 | rs479879 | chr10:105945985 | C10orf79 | chr10:105889647-105992120:- | 0.26 | 8.51 | 2.23E-16 | Attention deficit hyperactivity disorder |
| THCA | cis | rs12960119 | 1 | rs4800243 | chr18:23719196 | SS18 | chr18:23596219-23671164:- | 0.29 | 3.74 | 0.000205 | Rhegmatogenous retinal detachment |
| THCA | cis | rs12960119 | 1 | rs4800244 | chr18:23729222 | SS18 | chr18:23596219-23671164:- | 0.28 | 3.51 | 0.000493 | Rhegmatogenous retinal detachment |
| THCA | cis | rs12960119 | 1 | rs4800719 | chr18:23719536 | SS18 | chr18:23596219-23671164:- | 0.28 | 3.55 | 0.000425 | Rhegmatogenous retinal detachment |
| THCA | cis | rs2005199 | 1 | rs4801872 | chr19:52025017 | SIGLEC6 | chr19:52022784-52035064:- | -0.31 | -3.85 | 0.000136 | Carotid intima media thickness |
| THCA | cis | rs2005199 | 1 | rs4801872 | chr19:52025017 | ZNF175 | chr19:52074531-52092990:+ | -0.37 | -4.55 | 6.78E-6 | Carotid intima media thickness |
| THCA | cis | rs1133146 | 1 | rs4801958 | chr19:53667804 | ZNF665 | chr19:53666552-53696619:- | -0.15 | -4.1 | 4.83E-5 | Yu-Zhi constitution type in type 2 diabetes |
| THCA | cis | rs1133146 | 1 | rs4801961 | chr19:53676430 | ZNF665 | chr19:53666552-53696619:- | -0.16 | -4.5 | 8.72E-6 | Yu-Zhi constitution type in type 2 diabetes |
| THCA | cis | rs3760982 | 1 | rs4802200 | chr19:44289518 | LYPD5 | chr19:44300080-44324808:- | -0.24 | -5.19 | 3.05E-7 | Breast cancer |
| THCA | cis | rs3760982 | 1 | rs4802200 | chr19:44289518 | ZNF155 | chr19:44488355-44502477:+ | -0.25 | -5.62 | 3.33E-8 | Breast cancer |
| THCA | cis | rs3760982 | 1 | rs4802200 | chr19:44289518 | ZNF404 | chr19:44376516-44384288:- | -0.25 | -6.53 | 1.65E-10 | Breast cancer |
| THCA | cis | rs4802307 | 1 | rs4802307 | chr19:46849806 | PPP5C | chr19:46850294-46894103:+ | -0.24 | -4.22 | 2.92E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs2005199 | 1 | rs4802803 | chr19:52027587 | SIGLEC6 | chr19:52022784-52035064:- | -0.28 | -3.36 | 0.000838 | Carotid intima media thickness |